WebFeb 18, 2024 · Cullin-RING E3 ubiquitin ligases (CRLs) direct protein degradation to impact a myriad of physiological and pathological processes including cancer. This work reports the small-molecule compounds 33-11 and KH-4-43 as … WebCullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-∆9).
Phosphorylation regulates cullin-based ubiquitination in …
WebThe E3 ubiquitin ligase TRIM50 promotes the formation and degradation of ubiquitinated proteins through its interaction with HDAC6 (Fusco et al. 2012), and the Cullin3 (SPP) ubiquitin E3 ligase... WebCUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division ( Sumara et al., 2007 ). Cloning and Expression Kipreos et al. (1996) identified a conserved gene family, designated cullins (see CUL1, 603134 ), with at least 5 members in nematodes, 6 in humans, and 3 in S. cerevisiae. Human CUL3 is an ortholog of nematode cul3. the thing japanese poster
Cells Free Full-Text CUL4-DDB1-CRBN E3 Ubiquitin Ligase …
Cullin 3 is a component of Cullin-RING E3 ubiquitin ligases complexes (CRLs) which are involved in protein ubiquitylation and represent a part of ubiquitin–proteasome system (UPS). Added ubiquitin moieties to the lysine residue by CRLs then target the protein for the proteasomal degradation. … See more Cullin 3 is a protein that in humans is encoded by the CUL3 gene. Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, … See more Familial hyperkalemic hypertension Mutations in CUL3 gene are associated with Familial hyperkalemic hypertension disease. CRL complex containing Cullin 3 controls the activity of Na Cl cotransporter (NCC) in the kidney by regulating the proteasomal … See more • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. • Yu W, Andersson … See more CUL3 has been shown to interact with: • CAND1, • Cyclin E1, • DCUN1D1, • KEAP1, and See more • Human CUL3 genome location and CUL3 gene details page in the UCSC Genome Browser. See more WebTo test the hypothesis that cullin RING ligases may regulate ClC-2 protein expression, we employed a potent inhibitor of cullin RING E3 ligases, MLN4924 [38,39]. As illustrated in Figure 1 B, the 24-h treatment with 10 μM MLN4924 induced a significant enhancement … WebApr 12, 2024 · The damaged DNA-binding protein 1 (DDB1) enhances the survival and maintenance of multipotent cells through promoting the Cullin 4 E3 ligase complex-dependent ubiquitination and subsequent degradation of downstream substrates. Naive T cells could be activated and differentiated into effector and memory T cells by exogenous … the thing jack kirby